Shape–motion relationships of centering microtubule asters
نویسندگان
چکیده
منابع مشابه
Shape–motion relationships of centering microtubule asters
Although mechanisms that contribute to microtubule (MT) aster positioning have been extensively studied, still little is known on how asters move inside cells to faithfully target a cellular location. Here, we study sperm aster centration in sea urchin eggs, as a stereotypical large-scale aster movement with extreme constraints on centering speed and precision. By tracking three-dimensional ast...
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Fragments of fish melanophore cells can form and center aggregates of pigment granules by dynein-motor-driven transport along a self-organized radial array of microtubules (MTs). We present a quantitative model that describes pigment aggregation and MT-aster self-organization and the subsequent centering of both structures. The model is based on the observations that MTs are immobile and treadm...
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Self organization of the kinesin-microtubule system was implemented as a novel template to create percolated nanofiber networks. Asters of microtubule seeds were immobilized on glass surfaces and their growth was recorded over time. The individual aster islands became interconnected as microtubules grew and overlapped, resulting in a highly percolated network. Cellulose nanowhiskers were used t...
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Intracellular organization depends on a variety of molecular assembly processes; while some of these have been studied in simplified cell-free systems, others depend on the confined geometry of cells and cannot be reconstructed using bulk techniques. To study the latter processes in vitro, we fabricated microscopic chambers that simulate the closed environment of cells. We used these chambers t...
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Polar arrays of microtubules play many important roles in the cell. Normally, such arrays are organized by a centrosome anchoring the minus ends of the microtubules, while the plus ends extend to the cell periphery. However, ensembles of molecular motors and microtubules also demonstrate the ability to self-organize into polar arrays. We use quantitative modeling to analyze the self-organizatio...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2016
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201510064